Recombinant Proteins for Organoid Culture
| Cat No. | R-022 |
| Product Type | Growth factor |
| Molecular Weight | 34.1 kDa |
| Sterility | Negative |
| MyCoplasma | Negative |
| Purity | ≥ 90% as determined by SDS-PAGE; ≥ 95% as determined by SEC-MALS |
| Expression System | Human 293 cells (HEK293) |
| Formulation | Lyophilized from 0.22 μm filtered solution in PBS, pH7.4 with trehalose as protectant. |
| Reconstitution | Please refer to the Certificate of Analysis (CoA) for specific reconstitution instructions. |
| Shipping Info | Ice |
| Stability & Storage | Store frozen at -20 °C (short-term) or -80°C (long-term) |
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Recombinant Human IGF-I Protein, Fc Tag, is a recombinant growth factor designed to support advanced organoid culture systems with high purity and reproducibility. Insulin-like Growth Factor I (IGF-I), is the dominant effector of Growth Hormone (GH) and is structurally homologous to Proinsulin. The 7.6 kDa mature IGFI is identical between isoforms and is generated by proteolytic removal of the N- and C-terminal regions. Mature human IGF-I shares 94% and 96% amino acid (aa) sequence identity with the mouse and rat orthologs, respectively. The body growth of animals is regulated by growth hormone and IGF-I. The classical theory of this regulation is that most IGF-I in the blood originates in the liver and that body growth is controlled by the concentration of IGF-I in the blood. Meanwhile, IGF-I has been shown to enhance neuronal survival and inhibit apoptosis. IGF-1 promote the proliferation of multiple myeloma (MM) cells and protect them against dexamethasone (Dex)-induced apoptosis.
For research use only.
Whether you're exploring disease mechanisms or screening novel therapeutics, OgCelix is your trusted partner.
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Whether you're exploring disease mechanisms or screening novel therapeutics, OgCelix is your trusted partner.
Let's build the future of translational research together.
