Cat No.R-024
Product TypeGrowth factor
Molecular Weight9.5 kDa
SterilityNegative
MyCoplasmaNegative
Purity≥ 90% as determined by SDS-PAGE.
Expression SystemHuman 293 cells (HEK293)
FormulationLyophilized from 0.22 μm filtered solution in PBS, pH7.4 with trehalose as protectant.
ReconstitutionPlease refer to the Certificate of Analysis (CoA) for specific reconstitution instructions.
Shipping InfoIce
Stability & StorageStore frozen at -20 °C (short-term) or -80°C (long-term)

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Description

Recombinant Human IGF-I Protein, His Tag, is a recombinant growth factor designed for high-purity, reproducible performance in advanced culture systems. Insulin-like Growth Factor I (IGF-I), is the dominant effector of Growth Hormone (GH) and is structurally homologous to Proinsulin. TMature human IGF-I shares 94% and 96% amino acid (aa) sequence identity with the mouse and rat orthologs, respectively. The body growth of animals is regulated by growth hormone and IGF-I. The classical theory of this regulation is that most IGF-I in the blood originates in the liver and that body growth is controlled by the concentration of IGF-I in the blood. Meanwhile, IGF-I has been shown to enhance neuronal survival and inhibit apoptosis. IGF-1 promote the proliferation of multiple myeloma (MM) cells and protect them against dexamethasone (Dex)-induced apoptosis.optimized stability, it is a trusted reagent for regenerative medicine and developmental biology.

Specifications & Applications

Application

For research use only.

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