Cat No.R-039
Product TypeGrowth factor
Molecular Weight12.8 kDa
SterilityNegative
MyCoplasmaNegative
Purity≥ 95% as determined by SDS-PAGE
Expression SystemHuman 293 cells (HEK293)
FormulationLyophilized from 0.22 μm filtered solution in 100 mM Acetic Acid, pH2.8 with trehalose as protectant.
ReconstitutionPlease refer to the Certificate of Analysis (CoA) for specific reconstitution instructions.
Shipping InfoIce
Stability & StorageStore frozen at -20 °C (short-term) or -80°C (long-term)

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Description

Recombinant Human BMP-2 Protein, Premium Grade, is a recombinant growth factor for advanced culture systems, offering high-purity, reproducible performance. Bone morphogenetic protein 2 (BMP-2) is a pleiotropic ligand protein belonging to TGFβ family, and is involved in key embryonic development of vascular and valvular homeostasis. BMP-2 binds to type I receptors (ALK-2/-3/-6) and type II receptors (BMPR2, ACVR2A) to regulate various types of calcification, including atherosclerosis, chronic kidney disease, diabetes, and valve calcification. BMP-2 is overexpressed by myofibroblast and preosteoblast in the calcified area of human calcified valve, which are densely infiltrated by B lymphocytes and T lymphocytes.

Specifications & Applications

Application

For research use only.

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Let's build the future of translational research together.

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