3D Ready Organoid
| Cat No. | C-013 |
| Organism | Human |
| Tissue | Colon |
| Disease | Cancer |
| Growth Properties | Embedded 3D Culture |
| Biosafety Level | 1 |
| Growth conditions | 37℃, 95% Air, 5% CO2 |
| Size/Quantity | 1 |
| Product format | Frozen |
| Shipping Info | Dry Ice |
| Storage conditions | Liquid Nitrogen |
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Human Patient-Derived Colorectal Cancer Organoid – Sigmoid Colon APC, TP53, KRAS (G13D), SMAD4 is a 3D tumor model derived from the sigmoid colon of a colorectal cancer patient, featuring mutations in APC, TP53, KRAS (G13D), and SMAD4. This combination reflects a clinically aggressive colorectal cancer subtype characterized by deregulated Wnt, p53, RAS/MAPK, and TGF-β signaling. The organoid retains the original tumor’s architecture, mutation profile, and cellular heterogeneity. It supports long-term expansion and provides a robust platform for modeling molecular interactions and therapeutic responses in colorectal cancer.
Embedded 3D Culture
All test negative for mycoplasma, bacteria, yeast, and fungi.
For research use only. Human Patient-Derived Colorectal Cancer Organoid – Sigmoid Colon APC, TP53, KRAS (G13D), SMAD4 is ideal for testing targeted inhibitors against KRAS mutations, as well as combinational strategies involving Wnt and TGF-β pathway modulation. It facilitates studies on tumor heterogeneity, therapy resistance, and biomarker discovery. As a genetically complex model, it enables precision oncology applications and drug development tailored to mutation-specific colorectal cancer. Its in vitro stability makes it a powerful tool for translational research and personalized treatment evaluation.
Whether you're exploring disease mechanisms or screening novel therapeutics, OgCelix is your trusted partner.
Let's build the future of translational research together.
Whether you're exploring disease mechanisms or screening novel therapeutics, OgCelix is your trusted partner.
Let's build the future of translational research together.
