Human Patient-Derived Colorectal Cancer Organoid – Sigmoid Colon APC, TP53, SMAD4 C-012

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Cat No.	C-012
Organism	Human
Tissue	Colon
Disease	Cancer
Growth Properties	Embedded 3D Culture
Biosafety Level	1
Growth conditions	37℃, 95% Air, 5% CO2
Size/Quantity	1
Product format	Frozen
Shipping Info	Dry Ice
Storage conditions	Liquid Nitrogen

AcceGen Frozen Cells & Cell Lines 1 vial

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Description

Human Patient-Derived Colorectal Cancer Organoid – Sigmoid Colon APC, TP53, SMAD4 is a 3D tumor model cultured from sigmoid colon tissue of a colorectal cancer patient. This organoid harbors key oncogenic mutations in APC, TP53, and SMAD4, representative of advanced colorectal cancer with dysregulated Wnt signaling, impaired DNA damage response, and TGF-β pathway disruption. It preserves the histological structure, genetic integrity, and tumor heterogeneity of the original tissue. The organoid supports sustained in vitro growth, making it ideal for research in site-specific colorectal cancer progression and therapy response.

Specifications & Applications

Growth Properties

Embedded 3D Culture

Quality Control

All test negative for mycoplasma, bacteria, yeast, and fungi.

Application

For research use only. Human Patient-Derived Colorectal Cancer Organoid – Sigmoid Colon APC, TP53, SMAD4 model is highly relevant for investigating targeted therapies against Wnt and TGF-β pathways, understanding the synergy of multiple driver mutations, and validating new treatment combinations. It enables functional assays to evaluate drug resistance, biomarker identification, and tumor evolution. As a representative model of mutation-enriched sigmoid colon cancer, it supports personalized therapy development and translational research into molecularly stratified treatment strategies.

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